Dynamic Disease Screening: An Approach For Disease Early Detection and Prevention
In our daily life, we often need to identify individuals whose longitudinal patterns of some risk factors of a disease in concern are different from the patterns of those well-functioning individuals, so that some unpleasant consequences can be avoided. In many such applications, observations of a given individual are obtained sequentially, and it is desirable to have a screening system to give a signal as soon as that individual's longitudinal pattern starts to deviate from the regular pattern so that some adjustments or interventions can be made in a timely manner. We propose a dynamic disease screening system for that purpose, using statistical process control and longitudinal data analysis techniques. Our proposed method is demonstrated using a real-data example about the SHARe Framingham Heart Study of the National Heart, Lung and Blood Institute. This is a joint research with my collaborators Drs. Jun Li, Dongdong Xiang and Changliang Zou.